Police in Florida say they arrested the former president of a local chapter of Mom's Against Drunk Driving for driving below the affect. The exception to the rule is the DOT1 household, members of which methylate K79 within the globular region of histone H3 and which are structurally not related to SET-domain proteins 4 - 6 Recent work suggests that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)